Tranexamic Acid Improves Outcomes in Facial Rejuvenation Surgery, New Study Finds

A new study published in Plastic and Reconstructive Surgery – Global Open has found that using tranexamic acid (TXA) during facial rejuvenation surgery can significantly improve outcomes for patients. 🧑‍⚕️💉

The retrospective study, conducted at Clinica Ziegler in Lima, Peru, examined 100 patients undergoing multiplane facial rhytidectomy (facelift) procedures. Half of the patients received TXA both intravenously and through local infiltration, while the other half did not receive TXA.

Key findings include:

• Intraoperative bleeding was reduced by more than half in the TXA group (40 mL vs 90 mL) 🩸
• Operative time decreased by about 2 hours (237 minutes vs 353 minutes) ⏱️
• Significantly less postoperative ecchymosis (bruising) in TXA group (2% vs 36%) 
• Dramatically reduced postoperative edema (swelling) with TXA (2% vs 100%)
• Time to drain removal cut in half (3 days vs 6 days) 📅

While hematoma rates were similar between groups, the TXA group showed trends toward fewer hematomas overall. Importantly, there were no increased complications or adverse events associated with TXA use.

“These results demonstrate that TXA can significantly improve both intraoperative factors and postoperative recovery for facial rejuvenation patients,” said lead author Dr. Otto Ziegler Rodriguez. “The reduction in bleeding, operative time, and postoperative swelling and bruising could lead to better outcomes and patient satisfaction.”

The study represents one of the largest cohorts to date examining TXA use specifically in facial rejuvenation procedures. The authors note that further prospective randomized trials are needed to confirm the findings and provide stronger clinical recommendations.

For plastic surgeons and patients considering facial rejuvenation surgery, this study provides compelling evidence that TXA may be a valuable addition to improve surgical outcomes and recovery. As always, patients should discuss the potential risks and benefits with their surgeon when deciding on any surgical approach.

FYI, I have used TXA for my facelift patients for several years, and yes, it reduces swelling, bruising, and healing time in my patients.  A secret medication that is no longer a secret for faster results! 

The full study can be accessed HERE.