What is Rejuran?

Rejuran is a revolutionary skin treatment developed by a Korean company that has taken the aesthetic world by storm. Unlike traditional fillers, Rejuran is not merely a volumizing agent but a regenerative booster derived from salmon DNA. Specifically, it uses polynucleotides (PN), which are DNA fragments that stimulate the body’s natural healing processes. This treatment is popular in several Asian countries, including Korea and Singapore, and is slowly making its way to other parts of the world.

 

The Science Behind Rejuran

Rejuran is derived from an unusual source: salmon ejaculate, also known as salmon “milt.” The DNA extracted from this source is processed to create polynucleotides (PN) or polydeoxyribonucleotides (PDRN). These polynucleotides are highly compatible with human skin and help activate fibroblasts, the cells responsible for producing collagen and repairing tissue. When injected into the skin, Rejuran promotes tissue repair, angiogenesis (the formation of new blood vessels), and improved oxygenation, leading to healthier and rejuvenated skin.

 

Benefits of Rejuran

Rejuran offers a myriad of benefits, making it a versatile treatment for various skin concerns:

 

• Improved Skin Elasticity and Hydration: Rejuran helps enhance skin elasticity and hydration, making the skin appear more youthful and supple.
• Reduction of Fine Lines and Wrinkles: By stimulating collagen production, Rejuran can reduce the appearance of fine lines and wrinkles.
• Enhanced Skin Texture and Tone: The treatment improves overall skin texture and tone, reducing the visibility of pores and acne scars.
• Wound Healing and Regeneration: Initially developed for wound healing, Rejuran has been shown to improve conditions such as diabetic foot ulcers and pressure sores.
• UV Protection: Interestingly, Rejuran also offers some protection against UVB rays, adding an extra layer of defense against sun damage.
• Anti-Inflammatory and Anti-Ischemic Properties: Rejuran helps reduce inflammation and improve blood flow, promoting better skin health.

 

Clinical Evidence and Applications

Numerous studies have demonstrated the efficacy of Rejuran in various medical and aesthetic applications:

 

• Skin Graft Studies: Rejuran has been shown to improve wound healing and skin graft take.
• Intramuscular Injections for Diabetic Foot Ulcers: Clinical trials have demonstrated significant improvements in diabetic foot ulcers.
• Gel Form for Pressure Ulcers: Rejuran gel has been effective in treating pressure sores.
• Hair Loss Treatment: Topical application of Rejuran has shown promising results in reducing hair loss.

 

Why Salmon DNA?

Salmon DNA is chosen for its high compatibility with human skin. The polynucleotides derived from salmon DNA are easily integrated into human cells, making them highly effective for regenerative purposes.

 

Different Forms for Human Use

Rejuran is available in various forms and concentrations to cater to different treatment needs:

 

• Just PN: Pure polynucleotide for targeted regenerative treatments.
• PN Plus HA: A combination of polynucleotide and hyaluronic acid for enhanced hydration and volumization.
• Skin Booster Syringe: For broad skin rejuvenation, Rejuran can be injected using a micro-needling gun or manually with tiny injections just under the skin surface.

 

Treatment Protocol and Results

Typically, a series of treatments is recommended for optimal results. Most practitioners suggest one treatment every four weeks, with a total of three to six sessions depending on the patient’s needs. Patients can expect to see results in 3-4 weeks, with improvements in skin texture, quality, and thickness. The downtime is minimal, with most patients experiencing mild redness and swelling that subsides within a few days.

 

Conclusion

Rejuran represents a significant advancement in the field of aesthetic medicine, offering a unique combination of regenerative and protective benefits. Whether you’re looking to reduce wrinkles, improve skin texture, or enhance overall skin health, Rejuran provides a versatile and effective solution. As it continues to gain popularity worldwide, it will be interesting to see how this innovative treatment transforms the landscape of skin rejuvenation.

 

Scientific Evidence Supporting Rejuran’s Regenerative Properties

Multiple studies have demonstrated Rejuran’s potential for tissue regeneration and wound healing:

 

A comprehensive review by Squadrito et al. (2017) highlighted that polydeoxyribonucleotide (PDRN), the key component in Rejuran, promotes tissue repair, angiogenesis, and wound healing through activation of adenosine A2A receptors[1]. The study noted PDRN’s effectiveness in treating diabetic foot ulcers, pressure sores, and improving skin graft healing.

 

Research by Chung et al. (2020) found that PDRN injections significantly improved wound healing in a mouse model by enhancing angiogenesis and reducing inflammation[2]. The treatment increased expression of growth factors like VEGF and reduced pro-inflammatory cytokines.

 

A clinical study by Park et al. (2018) demonstrated that intradermal PDRN injections improved skin hydration, elasticity, and dermal density in patients with photoaged skin[3]. The researchers observed increased collagen and elastin production in skin biopsies.

 

Seo et al. (2018) reported that PDRN treatment accelerated wound healing in human dermal fibroblasts by promoting cell migration and proliferation[4]. The study found PDRN upregulated genes involved in extracellular matrix production and tissue remodeling.

 

Finally, a review by Kang et al. (2021) summarized PDRN’s diverse therapeutic applications, including skin rejuvenation, wound healing, and hair growth promotion[5]. The authors noted PDRN’s ability to stimulate the salvage pathway for DNA repair and activate adenosine receptors as key mechanisms.

 

These studies provide strong scientific evidence for Rejuran’s regenerative and wound healing properties, supporting its use in aesthetic and medical applications. The consistent findings across multiple research groups highlight PDRN’s potential to promote tissue repair and skin rejuvenation through various cellular mechanisms.

 

Fun Fact

Did you know that male fish ejaculate is called “milt“? Now you know!

If you have any questions about Rejuran or are excited to try this salmon DNA-derived product, feel free to reach out to your local aesthetic clinic for more information.

Currently, the injectable form of Rejuran is NOT available in the US.  We shall see if and when it gets FDA approved!